PubChem Proteins

PubChem Protein pages present PubChem data available for a given protein. The information presented on these pages includes bioactivity data of chemicals that are tested against the corresponding protein, along with annotations on the protein collected from authoritative and curated sources.

More detailed information on PubChem Protein pages can be found in the following paper:

Kim S, Cheng T, He S, Thiessen PA, Li Q, Gindulyte A, Bolton EE. PubChem Protein, Gene, Pathway, and Taxonomy Data Collections: Bridging Biology and Chemistry through Target-Centric Views of PubChem Data. J Mol Biol. 2022 Feb 25:167514. doi:10.1016/j.jmb.2022.167514. Epub ahead of print. PMID: 35227770.
[PubMed PMID: 35227770] [Free Full Text]

Protein Example:

If you would like a summary of what is known about the activity of the protein Epidermal growth factor receptor, just go to this webpage:

https://pubchem.ncbi.nlm.nih.gov/protein/P00533

Programmatic access

The annotation data presented on the Protein pages can be downloaded programmatically through PubChem's REST-like interface called PUG-View.

The PUG-View request URLs contain a record identifier (e.g., NCBI protein accession), as shown in the following example:

Human Coagulation Factor X (protein accession P00742)
https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/protein/P00742/JSON

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PubChem Proteins

Protein Example:

Programmatic access

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