Laboratory Chemical Safety Summary (LCSS)


The Laboratory Chemical Safety Summary (LCSS) is based on the format described by the National Research Council in the publication "Prudent Practices in the Laboratory: Handling and Management of Chemical Hazards" (2011) (see reference below). The LCSS in PubChem contains pertinent chemical hazard and safety information. It is available when a GHS Classification (Globally Harmonized System of Classification and Labeling of Chemicals) is present for a given PubChem Compound record. The GHS classification codes and hazard pictograms are summarized in the PubChem GHS page.


The LCSS provided by PubChem is intended to augment, not replace, safe laboratory practices and procedures for chemical information, such as those found in chemical inventory management systems or laboratory-specific personal protective equipment information. It is the responsibility of PubChem users to determine applicability of or gaps in the LCSS information to support safe use of a chemical. In addition, laboratory risks can arise not only from the specific chemicals used, but also from 1) changes in the concentrations and quantities of those chemicals, 2) new chemicals that are produced, 3) energy sources that occur during a laboratory process, and other variables. For more information, see this newsletter article as well as this PubChem Blog post.


The electronic form of the LCSS provided by PubChem is publicly accessible. LCSS data can be downloaded as a data stream in bulk or on-demand from the PubChem website (e.g., by following a link on a compound summary page). Although we are not aware of any limitations or restrictions on the reuse of PubChem LCSS data, we are not able to give unconditional permission for reuse and advise consultation with intellectual property experts when reusing this data. See disclaimer below for more information.





National Research Council. Prudent Practices in the Laboratory: Handling and Management of Chemical Hazards, Updated Version. Washington, DC: The National Academies Press, 2011. Free PDF available from


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